八十七年度中西醫藥對骨質疏鬆症防治的基礎與臨床研究研討會論文摘要

八十七年度中西醫藥對骨質疏鬆症防治的基礎與臨床研究研討會論文摘要

Decrescent Changes in Bone Mineral Density in Climacteric Perimenopausal Chinese Women

Teen-Meei Wang 1

Chung-Gwo Chang 2

Chang-Hai Tsai 3

1Departments of Dentistry and 3Pediatrics, China Medical College Hospital,Taichung, Taiwan, ROC

2Committee on Chinese Medicine and Pharmacy, Department of Health, Executive Yuan, Taipei and School of Chinese Medicine, China Medical College, Taichung , Taiwan, ROC.

The development of modern Chinese medicine and western medicine caused aprolongation of life span of human being.

Age-related changes in bone mineral density(BMD)contribute to the risk of fratures in aged people and estrogen-related changes in BMD lead to the risk of osteoporosis in postmenopausal women.

Osteoporosis is closely related with the symptom of low- back pain or fracture in the axial and/or appendicular skeleton.

It is a prevalentbone disease on the patient in the out-patient department (OPD) of the Chinese internal medicine, bone traumatology,gerontology, family medicine,orthopaedics, endocrinology and gynecology and obstetrics, clinically.

For the reason of precise diagnosis in clinicalpractice,the individual value of BMD has to be compared a reference value before a clinical decision is made. To describe the relationship between age and BMD in climacteric perimenopausal women for the diagnosis of osteoporosis is necessary, especially using Chinese data base is inevitable.

The purpose of this study was to investigate the value of BMD at each age level for climacteric perimenopausal Chinese healthy women on Taiwan for the reference of diagnosis, prevention and treatment of osteoporotic patient and research of osteoporosis.

Fourteen hundred and five women in age ranging from 40 to 60 years old were recruited from the cities in Taiwan district, Republic of China including off-shore islands and were invited in for bone mineral measurement by using single energy x-ray absorptiometry (OsteoAnalyzer SXA 2000) and assessment of health and factors of importance for BMD. In total, eighty one individuals were excluded from the investigation according to predetermined exclusion criteria, whereas 1324 females met all inclusion criteria and entered the reference population sample.

We found the age of spontaneous menopause in Chinese women was 47.43 years old and a strong inverse relationship between BMD and age 40-60 years old for the calcaneus. Obvious decrements in BMD between women aged 47-48 years in calcaneus, where the difference of BMD below the fracture threshold (325 mg/cm in this study) between the two age groups was nearly 4%.

The population percentage of BMD value below the fracture threshold in 60 years old group was exceeding 47% which exhibited the largest and then followed by exceeding 33% in 59 years old group. We conclude that the obvious BMD decrements in the postmenopausal women when compared to the premenopausal women and inverse relationship between age and fracture in Chinese healthy women.

A suggestion for the diagnosis, prevention and treatment of osteoporosis by the physician to the osteopenic women, especially during the climacteric perimenopausal period is needed.

:: 行政院衛生署中醫藥委員會