Thieme-connect / Abstract
Original Paper
Planta Med 2000; 66: 694-698DOI: 10.1055/s-2000-9775
Original Paper
Planta Med 2000; 66: 694-698DOI: 10.1055/s-2000-9775
Anti-Hepatitis B Virus Effects of Wogonin Isolated from Scutellaria baicalensis
Ray-Ling Huang1,*, Chien-Chih Chen1, Huey-Lan Huang2, Chung-Gwo Chang3, Chieh-Fu Chen1, Chungming Chang2, Ming-Tsuen Hsieh3
1 Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
2 Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan, R.O.C.
3 Department of Chinese Medicine, China Medical College, Taichung, Taiwan, R.O.C.
Abstract
By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production
By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.
Key words
Human hepatitis B virus - HBsAg - HBeAg - endogenous polymerase activity - Scutellaria baicalensis - Labiatae - wogonin - baicalein - baicalin
1 Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
2 Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan, R.O.C.
3 Department of Chinese Medicine, China Medical College, Taichung, Taiwan, R.O.C.
Abstract
By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production
By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.
Key words
Human hepatitis B virus - HBsAg - HBeAg - endogenous polymerase activity - Scutellaria baicalensis - Labiatae - wogonin - baicalein - baicalin
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